Erhaltungstherapie mit Methadontabletten - Eine Übersicht
Erhaltungstherapie mit Methadontabletten - Eine Übersicht
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Patients should be cautioned that methadone, like other opioids, may produce orthostatic hypotension in ambulatory patients.
The usual precautions appropriate to the use of parenteral opioids should Beryllium observed and the possibility of respiratory depression should always Beryllium kept hinein mind.
Accidental or deliberate ingestion by a child may cause respiratory depression that can result hinein death. Patients and caregivers should Beryllium instructed to keep methadone rein a secure place out of the reach of children and to discard unused methadone in such a way that individuals other than the patient for whom it welches originally prescribed will not come hinein contact with the drug.
Selection of patients for treatment with methadone should be governed by the same principles that apply to the use of other opioids (Weiher INDICATIONS AND USAGE).
Due to the opioid tolerance induced by methadone, when opioids are required for management of acute pain rein methadone patients, somewhat higher and/or more frequent doses will often Beryllium required than would Beryllium the case for non-tolerant patients.
This drug can make you very drowsy. You shouldn’t Methadontabletten 10 mg online drive, use machinery, or do other activities that require alertness after you’ve taken this drug.
The administration of opioids may obscure the diagnosis or clinical course of patients with acute abdominal conditions.
Rifampin – In patients well-stabilized on methadone, concomitant administration of rifampin resulted in a marked reduction in serum methadone levels and a concurrent appearance of withdrawal symptoms.
For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.
The safety and effectiveness of this drug hasn’t been established rein children. It shouldn’t be used in children younger than 18 years.
Certified treatment programs shall dispense and use methadone rein oral form only and according to the treatment requirements stipulated hinein the Federal Opioid Treatment Standards (42 CFR 8.12). See below for important regulatory exceptions to the general requirement for certification to provide opioid agonist treatment.
Some data also indicate that methadone acts as an antagonist at the N-methyl-D-aspartate (NMDA) receptor. The contribution of NMDA receptor antagonism to methadone's efficacy is unknown. Other NMDA receptor antagonists have been shown to produce neurotoxic effects in animals.
Desipramine – Blood levels of desipramine have increased with concurrent methadone administration.
For children: The safety and effectiveness of this drug haven’t been established hinein children. It shouldn’t be used in children younger than 18 years. Children Weltgesundheitsorganisation accidentally take this drug have a high risk of death from overdosing.